I have been taking Effexor XR for about 4 years. I take 225 mg. in the morning. The only side effect I experienced was an increase in anxiety and insomnia. I was taking it in combination with Ativan, but became concerned about the addictive properties and new studies that show benzodiazepines prevent the brain from learning new information and effect memory. I now take Buspar and am adding vitamins and supplements (Sam-e, Kava Kava, GABA, 5-htp) that are supposed to decrease depression and anxiety. I have tried many other anti-depressants over the years and didn't have any luck with them. I don't expect a pill to be a magic cure, though. I also exercise, attend support groups, watch my diet, and keep my days structured and full of activities.
I hope this is helpful information.

scooterb (Lisa)