No, Buproprion is used "on label" for smoking in the U.S. It is marketed for this purpose under the trade name, "Zyban." WeepingWillow, if you want to try Buproprion for depression and it is only available on label for anti-smoking in the UK, couldn't your doctor prescribe it for you even though you really want it for depression? Or don't they do off-label prescribing in the UK?

Buproprion, the generic of Wellbutrin, is very popular for depression in the U.S. I hadn't heard it is falling from favor. IMO, it is underutilized. (Part of "falling from favor" may mean the drug has gone to generics so is not advertised heavily by its maker. Cymbalta, OTOH, is still not in generics, so is heavily advertised by its manufacturer.) Many people have trouble with the SSRIs, but these seem to be the "goto" entry drug for depression. People are usually not tried on Cymbalta until they have failed on SSRIs. Many people like Buproprion because it is activating, does not cause sexual dysfunction, and is not associated with weight gain. Some people use Buproprion in conjunction with an SSRI to help with the sexual issues. Cymbalta can be hell to come off of, but does help some people who are not helped by the SSRIs.

Agreed.