Everyone's chemistry is unique, but I too am bipolar and Paxil gave me a manic episode where I was doing dangerous things. Celexa made me irritable, tired, and have insomnia. So, SSRIs aren't necessarily good for bipolar depression. True, they work on some to relieve the depression. For me, only Wellbutrin has helped with energy for the day and no negative side effects. Effexor, an SSNRI, made me severely depressed after the shaking wore off.

I also have PTSD from childhood abuse. The Seroquel helped me get calm at night, not have so many intrusive thoughts and be able to sleep. Again, this is all my experience and yours may be different. If you've been diagnosed with bipolar I wonder why your Dr hasn't prescribed a mood stabilizer like Lamictal or Lithium. I haven't started Lamictal yet, but just got an Rx. I hear it prevents the swing into severe depression and doesn't interfere too much with hypomania, so you can still have good days where you can accomplish things. Hope this helps.