Yes very true, easygoer.......the correlation between adrenal excess and muscle tightness/ spasm........I get in in my calves!

There are other reasons it could be.......hormones(has your wife gone through menopause or is in perimenopause?), medication side-effects, magnesium deficiency, fibromyalgia, arthritis, constipation/ Irritable bowel syndrome, scoliosis(curvature of the spine) or pelvic rotation to name a few......

has she had complete physical in hospital? How old is she and, if you don't mind, what was she dx with?

It could be all psychological with physiological response......or......it is physiological and she is having a psychological response. I was misdx with Bipolar in 2007 and medicated......only to find out 4 months ago I was in perimenopause and that is what was making me so ill.......yep, hormones are the true keepers of the gate. If you wish to talk more about this, feel free to ask......

Hope that helps, babe.......take care and we are here.....