I have PTSD too, but never been prescribed Zoloft. I would guess that any anti-anxiety pill would help, but I'm no doctor. I'm on Seroquel (quietapine SP?) for sleep and to calm me down, especially with the frightening images I see when I try to fall asleep.

So no, I don't think that's the only kind of medication. I think you can add on different classes of meds if it's not having the desired effect.