Can a Vicodin overdose cause an ear infection? My T didn't seem surprised last week when I said the next morning I had ALOT of ear stuffiness--they felt really plugged! I was fine before the Vicodin. After my ears feeling so plugged went away, I've had mild sinus congestion. My left has been hurting the past few days so I went to the ER after work as it seemed almost continuous and not very pleasant. I have a slight infection going, but I after talking to my T last week and his reaction to my ears being plugged the next morning after I OD'd, I wonder if that's what caused this?