I took Seroquel for quite a while actually. I started on it almost 2 years ago at this point and was taking 50mg but I was like snowed. We decreased to 25mg and it wasn't much better so I stopped. Then last July (2008) I was in the hospital and didn't sleep for 4 days and they actually restarted he Seroquel at 12.5mg which worked like a charm. After a few months I increased it to 25mg, then increased it to 50mg and I wasn't having the morning hang over at all. It was really a great drug for me. I stopped because my pdoc started me on Lithium and thought I'd be fine without it.... that being said, I haven't slept well for like 5 months now since I started the Lithium!!! Maybe stepping back on the dose would be helpful for you. It's not a scored tablet so it's hard to break the little 25mg tab in half but my inpatient pdoc felt like if half works then great. Good luck!!