I have been on clozaril for 2 yrs and it has been a great med for me. I currently take 200 mgs at bedtime (I have been as high as 500) and it certainly helps me sleep ! But the real reason that I take it is for it's real help with my strong suicidal ideation and depression w/ psychotic features. I too had tried a number of anti-psychotics and this one I have actually stuck with! Yes, initially it is sedating, and that is why I would recommend that you take the entire amount at night. I also take provigil in the AM along with Effexor. For me the clozaril has been a good med and has definitly helped supplement my anti-depressants. Good luck and keep me posted on your feelings about the med. By the way.........the blood tests aren't that bad, you really get used to them quick. Take care!