Anyone here experience their meds stop working after a while of being on them? I have tried about a dozen antidepressants which have all crapped out on me after about (on average) 4-6 months (maximum dosage reached). What do you do then?? I'm afraid that no more meds will work on me. I've tried all the SSRI's, some old tricyclics, one MAOI, and some atypical ones as well. I do not want to go on anti-psychotics because of the weight gain side effect.

I am going through a very difficult time right now. My depression has almost lasted two years now. I am so very hopeless.

Any suggestions? Am I just a lost cause who is not treatable with meds?