For me effexor has been a wonderful med. I have been on it for 5 1/2 years and currently take 600 mg. in the morning. I find that taking it in the morning is the best for me, but I know of others who take it in the evening or split the dose between the two. The only real side effects were the "restless legs" that I had early on and definitly the extra sweating, especially at night. I hope the effexor works for you, but not to worry.....there are many meds out there and one is bound to work for you. Good luck and take care.