I have been on Seroquel for over a year at this point and havent had any side effects at all except for extreme sleepiness and a hangover in the morning (I take it at night). I should mention that I'm only on 25-50mg for sleep only. I have never taken above 50mg so I would think for those that are using it for control of your bipolar sx and are on 200-400mg or more it would certainly be possible for it to cause metabolic problems as can all drugs in the same class (atypical antipsychotics). Definitely discuss this with your pdoc... These meds can also potentially cause diabetes later down the road as well. I would say you're on your way to that between the weight gain and the high triglycerides (but moreso the weight gain). Good luck with this!!