I was on depakote for a year and I gained 40 pounds. It was becoming dangerous because I also have an eating disorder. I was weaned off of Depakote and placed on Topamax. Topamax has done me very well. It does help with weight loss. In the mornings I take 50mg of Topamax, 50mg of Zoloft. At night I take an additional 50mg of Topamax and 50mg of Zoloft along with 30mg of Celexa. I have been on this medicinal cocktail for a year now and it has done well for me.