What do you do if a med you're taking gives you bad side effects? Some wouldn't be tolerable at all, but what about ones you could maybe tolerate, but really bug you?

My latest combination gives me lots of shakiness, some stuttering, dry mouth and constipation. And they're not even working very well... but I've run out of time to try any more adjustments, with school about to start. I feel like what's the point? I take the meds to feel better, don't feel much better, and get more problems to deal with. I'm so sick of everything!