For me, saying I can't work at all anymore would be worse than anything so I have actually just been making job changes as I saw necessary. I was working a very, very busy, high acuity ER and I was hospitalized and when I came back I decided my rotating schedule wasn't working so I spoke with my boss and cut back hours and changed the area where I worked but it still wasn't enough so I had to resign from the ER altogether and started working in an outpatient office. Way different! With that job I was able to again work full time and was doing well at my job. I just moved and actually just agreed to a new job yesterday. It's in home care so again it's lower stress. I have no idea how I'm going to handle it but if it doesn't work out I'll just have to make another adjustment. I feel awful unless I'm working, even if it's not exactly what I want to be doing. If it were me, I would be talking to my boss to see if we could figure out what tasks were tolerable vs not tolerable and if things didn't change I'd look for a new job. I wouldn't be ruling out working all together unless I wasn't able to find anything in any situation that I could tolerate without having to be hospitalized or what-not. I wish you luck in figuring out the situation. Working and having bipolar disorder is really hard almost all the time. Keep us posted with what your boss says if you decide to talk with her.