I've heard that about higher doses of seroquel not having the sleep-inducing effect of the lower dose, but I've never taken enough to find out. My doctor started me out on a small dose of 25mg twice a day and upped it to 50 after a while, but I never got over the intense sleepiness. I couldn't accomplish anything while taking it - all I could do was sleep. It helped for a while since I was extremely sleep-deprived but it became counterproductive. I hope it works better for you. If it doesn't tho, speak to your doc about it asap.