Was doing a search on Zoloft and this thread came up. I was on Effexor for a while at 300 which was over the recommended dosage of 225. So we lowered it and I tolerated it for six months until headaches and what they call "brain zaps" (sharp pains behind the eyes) caused us to lower it more and add something else. Effexor has a sedative effect and that might be why it came up when talking about an antidepressant with an antianxiety quality to it.