My roommate isn't necessarily bi-polar, he is schizo-affective bi-polar type, but was originally diagnosed bi-polar. He just suffered an acute manic episode and was hsopitalized and is now placed on Depakote. I have been researching Depakote, especially in the area of anti-depressants used with Depakote, having a type of placebo affect. I have told this to my nurse what I have read but she said she spent plenty of time in school and had him on the right anti-depressant. It is Prozac and he is only depressed and irritable while taking it and it has increased with the use of Depakote, and I really wish he was switched to a different class of anti-depressants but don't know which one works well with Depakote. He is not assertive and I see the nurse in a short time now to have this discussion once again with her but if anyone was on Depakote, have you tolerated any particular anti-depressant better than others?

Thanks, Grithnir