It took a long time before I could find a combination that was able to give me back some kind of normal life. In many ways I was out of control, and antidepressants alone don't help me. I have a system that has a hypersensitive adrenaline response, which means every little stressor sends me off as if I were on meth. Same with caffeine or decongestants. On top of that I have the usual bipolar ups and downs which are largely, but not completely biological. SO, most people don't have this problem, like most people can drink one gals of wine or beerand stop. some of us need meds, like some people need to stop booze completely. It's just part of the wonderful world of genetic and behavioral variation