I am so sorry to hear that you are having such a rough time. My meds recently stopped being effective also. I haven't had time to talk to my P.Doc about it yet... but med changes of any form, I have found, are brutal. When I started on mine (Citalopram) I spent a week and a half dealing with the most brutal side effects that the drug had to offer. And they took about 6 weeks to really kick in. So the side effects were back dropped by my severe depression. It was miserable. And I am afraid to change meds and have to go through it again. I wish that there was something that I could say to make the situation better for you. You are very strong to push through this. I hoe that things even out for you, and if you ever need to vent, there are a lot of people here who are willing to listen to you.