I didn't like Depakote at all. It definitely made me feel sluggish and tired. Who feels good about themselvs when they're so tired they fall asleep at work? SO I get what you're saying when you say it makes you feel depressed. It's an awful feeling. I think it's a good idea to give it a few more weeks and go from there. YOu have to give it time, sometimes the side effects go away after a time. Hopefully you can work this out with your pdoc. Take care.