I've been dealing with unrelenting depression for about 20+ years now and trying to keep my thoughts within the realm of sanity is a constant struggle every day. It seems I've been on every med known to man for it too. I'm currently on Lamictal for bipolar symptoms which my Psych told me are a major issue. I tried Seroquel which I didn't like at all (zombie state) with no relief, most of the SSRI's also with little (at least to me) effect.........Talk therapy and the Lamictal (plus Buspar for anxiety) has been the best course for me so far......I feel pretty much like a human these days but from experience know this can change like the weather.........So know your not alone with your feelings.....just keep those positives going.......and keep posting....you have support here...Good Luck...Y