He might be less depressed if somebody helped him clean provided it didn't interfere with his System and make it impossible to find anything...

I keep my clean socks to the right of the pizza boxes, dirty to the left. Stacks of paper on the coffee table act as a giant coaster and saves me time looking for one. If I didn't leave the cobwebs hanging down the mosquitoes would get me. Dust, when disturbed, looks pretty in the slanting sunlight and cheers me up. If you leave your dishes in the sink long enough the bacteria will die of starvation.