Treehouse, I'm another one who has few if any side effects from Wellbutrin. It does not keep me up at night, does not make me gain weight, does not give me dry mouth, does not make me feel "not myself" or numb. My only side effect (after the first few days of strong activation) is that when I was on the 300 mg dose, my hands had tremors. It was scarely noticeable unless I tried to do certain things, like turn the pages of a book (hard!). Since I wasn't a brain surgeon or anything that really needly absolutely still hands, this was not a problem for me. Quite sometime later when I went back down to 150, this effect went away. I really think Wellbutrin has fewer side effects than many psych drugs. It is also easier to come off of than many ADs. If Wellbutrin does trigger a sort of manic reaction in you, remember, you can always stop taking it, or you can push on through for a few days of discomfort and maybe come out the other side feeling much better. You are in total control of this, treehouse. I think having your H pressuring you may not be helpful. Because of your worries, it might be good to start the med on a weekday, several days in advance of the weekend, when you will have better access to your doc in case you need advice about any reaction you may be having.