Thanks billiej...I was on effexor in the past and I had to go off of it because I was gaining 5 or more pounds per week, even though I hardly ate anything and at that time I was on a regular exercise routine. My regular doctor and my pdoc both said it was too dangerous to gain weight that quickly. Seroquel made me gain weight also, but it wasn't so sudden, I gained 4 or 5 pounds a month and I did eventually become overweight, but it finally did stabalize and the seroquel does work well for me. I think I was on Cymbalta at one point, but not with this particular combination of meds. I know you aren't trying to advertise, it is good to hear what has helped others even though I know that it might not work for me; it still gives me hope that I will also find something that will work, you know? Thanks for the well-wishes, I am glad I gave in and sought help before I reached crisis, that's a big step for me. In the past I would often put off seeing anyone until I had no choice but to be hospitalized.