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2: Sleep Med Rev 2002 Oct;6(5):361-77
Therapeutic use of sleep deprivation in depression.
Giedke H, Schwarzler F.
Department of Psychiatry, University of Tubingen, Osianderstr. 24, Germany.
henner.giedke@med.uni-tuebingen.de
Total sleep deprivation (TSD) for one whole night improves depressive symptoms
in 40-60% of treatments. The degree of clinical change spans a continuum from
complete remission to worsening (in 2-7%). Other side effects are sleepiness and
(hypo-) mania. Sleep deprivation (SD) response shows up in the SD night or on
the following day. Ten to 15% of patients respond after recovery sleep only.
After recovery sleep 50-80% of day 1 responders suffer a complete or partial
relapse; but improvement can last for weeks. Sleep seems to lead to relapse
although this is not necessarily the case. Treatment effects may be stabilised
by antidepressant drugs, lithium, shifting of sleep time or light therapy. The
best predictor of a therapeutic effect is a large variability of mood. Current
opinion is that partial sleep deprivation (PSD) in the second half of the night
is equally effective as TSD. There are, however, indications that TSD is
superior. Early PSD (i.e. sleeping between 3:00 and 6:00) has the same effect as
late PSD given equal sleep duration. New data cast doubt on the time-honoured
conviction that REM sleep deprivation is more effective than non-REM SD. Both
may work by reducing total sleep time. SD is an unspecific therapy. The main
indication is the depressive syndrome. Some studies show positive effects in
Parkinson's disease. It is still unknown how sleep deprivation works.
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Weird, if you ask me.. thinking.... What do they do with the increased suicide rates for depressed ppl who go without sleep? I'm thinking because this is THERAPEUTIC meaning you're in lock up, you can't do that??? Interesting. I'm not interested, I do enough non-sleep all nighters to figure it won't work for me!