depends on the side-effects and the drug really. Only just started on zoloft so can't say much about that one, but from my experience with other meds, there are side-effects you get when your body's getting used to the drug (eg upset stomach) but these go away after a couple of weeks. Other side-effects tend to stick around but if they're stuff you really can't deal with, your doctor can prescribe another drug with a different side-effect profile.

good luck - let me know if it works for you!

mildred