I have been on seroquel for 9 years now for sleep and managing my bipolar disorder. I can tell you that it is the strangest drug, but has been very effective for me. I have experimented with all different dosages, i've even tried seroquel xr. I went to see a new doctor last week and he told me it works differently depending on the dosage. What did that mean for me? I was down to 100mg a night just to make me groggy for bed. However, It wasn't working all that well and I started to have episodes of depression and acute mania. He told me I am not at therapudic level and to increse the dosage to 400mg/day. Bam!! I can sleep and my mood issues are gone. Medication affects everyone differently but I guess my point is the dosage makes a big difference in how the drug works. Good luck :-)