I know peoplw who have used a med holiday but only after having been on them and stable for quite a long time. Some of these people can stay off of them forever then. Maybe what you would like to do is a med wash, where you come off of all meds, see what your symptoms are 5-10 days after having stopped the meds, and then restart the appropriate meds. I'm not sure what your exact situation is, but like I said, it's typically the people who have been on medication for a long period of time and have been stable (like ten years or more) that they try the holiday on.