Seroquel made me sleep up to 14 hours a day. I was comatose and constantly depressed. Abilify made my heart race and I was anxious round the clock. I was in a manic episode when I was put on it, so that may have influenced my reaction to it. Wellbutrin seemed to do nothing for me, but if I was on too high a dose (300mg) it also made my heart race and caused anxiety. What is currently helping me, although not completely, is Geodon. All the other anti-psychotics have had negative side effects worse than it. But everyone is different as you can see from other people's posts. It's best to talk to a professional and go through the trial and error process, which can't be avoided, as frustrating as it is.