Thanks Perna .
I had a feeling there may be a slight problem with the tryptophan, however the GABA seems okay, I took some last night, I also took my second dose of Venlafaxine earlier in the day, this seemed to solve the problem. I had a bit of jumpiness, RLS but this had stopped when I went to bed. I'll avoid the tryptophan as I don't want to OD on serotonin !.