I have had more success with WB than with anything. I currently take 150mg 2x a day (first thing in the morning and at 3 p.m.) I have taken up to 400mg of WB a day.

I have tried a number of drugs in the past 4 years, but have taken WB consistently for the last 3. It's the only one that seems to work. I take it with Zoloft and Serzone right now, but will be off the Serzone next week. I started taking WB with Remeron three years ago, and it made quite a difference as an augment, but was even better when we reduced the Rem and made WB my primary AD. I also have taken it alone and with Celexa and Neurontin.

I found I had a lot of irritability and hand tremor whenever my dose was upped. That would last for about 2 weeks. I would completely cut out caffeine to help control the tremors. Eventually the irritability would wear off and I'd feel a burst of energy that lasted for about a week. In that time I got all sorts of things done -- cleaning the house, doing yardwork, whatever -- I just felt like moving around and getting stuff done. Then that wore off. Some people think that when the energy burst wears off, the drug has pooped out, but the opposite is true. Cam has said in the past that that is when the drug really begins to kick in (he's right). So be patient. Also, don't try to split the pills: they have a time-release coating, and if you break it, you lose the time-release benefit.

I was a little surprised to see how quickly you are titrating up to 300mg. Maybe it would be good to go more slowly so that the side fx will be more tolerable and you'll be able to give it a fair trial. WB comes in 100mg tablets too (they're blue sted of purple). If 150 is too much, maybe you could drop to 100mg daily for awhile, and then move to 150 1x day and then 100 2x a day, and so on. The only problem with that I found is that I had to go through the side effects every time I move up in dose. But if the drug works, it's worth the discomfort and inconvenience.

Regarding sleep, take the WB early. As I mentioned, I take it upon waking, and at around 3. I don't have trouble with sleep on this schedule. I also am pretty careful to follow my doctor's advice on "sleep hygiene":
-- waking up at the same time every day;
-- no caffeine, alcohol, nicotine;
-- no daytime naps;
-- exercise early in the day;
-- avoid evening stimulation such as TV (read or listen to the radio instead);
-- 20-min hot bath soaks or showers before bed;
-- eat at regular times and avoid large meals near bedtime;
-- practice evening relaxation routines such as progressive muscle relaxation or meditation;
-- and maintain comfortable sleeping conditions.

I also have hot herbal tea before bed sometimes.

That's about all I can think of. Happy to try to answer any questions. Good luck!

Posey

"Life and death, loss and possession are one: There falls no shadow where there shines no sun."
- Shakespeare