I use to have problem with isolation, especially on weekends. The longer I go without talking to anyone, the more my head takes up space inside itself :-) and the thoughts get out of control. I need interaction with "reality"/other people or I get to be a scary mess up there. At one point I made a "rule" and would go out and talk to any one person (store clerk, librarian, etc.) and that seemed to be enough to keep me half-sane :-)