While I've had highs and lows, I had a DRAMATIC, virtually overnight change once. I have OCD, and literally, I woke up one day after starting on Anafranil, and I was different. I suddenly could touch things I couldn't before, I didn't worry about things that made me nervous or anxious as much, and I felt freer. Most anxiety doesn't change that quickly, but yes, it is possible, and I'm the proof.