I did practically the same thing in May. I weaned myself off of the meds I didn't think were helping and lowered the dosages on some others that I thought were too strong. I told my p-doc about it in retrospect, and she was not pleased. But, she said she would continue to work with me because my mood had improved with the adjustments that I made. In June my depression spiked and I had to go back on an anti-dep, but it wasn't until late July that I got on one that actually worked for me: Cymbalta. My depression has been minimal to non-existent since the day I started it. I'm on some new meds, but I still have a reduced set compared to as say April. And this was my design. If I hadn't taken myself off of so many of my meds and reduced their dosage, it's possible the Cymbalta wouldn't have worked and become the missing link. All this to say, I support you in your decision so long as you're doing it carefully and gradually and adjusting back onto things if you feel your mood slipping. That's what I did. It feels good to have some control over your own body...especially if the p-doc won't listen to you. About a year ago the psych nurse I was seeing wouldn't let me come off of Seroquel which was diminishing my will to live. I came off of it, while still on Lamictal and Wellbutrin and went into a 9 week manic episode. It was more hypomanic than manic, but it was awesome. The crash was not so awesome though. So I've had mixed results with adjusting my meds. I wish you all the best in your journey to become well.