I just notice when my depession really start to hit.. I start getting some sort of cold. Luckly it doesn't effect my arthtitis(I know I am young to have it, but my due to my depession I have a body of a 26 year old it what some doctors have told me since I am 20)
And if you ever notice to look at cold mediences ingredients, they have some simlar things as an anti-depressant.. But I wounder if it only makes you feel worst.