I just uped my Zyprexa from 5mg to 10mg and all the benefit of the initial dose has returned. My mood has definitely stabilized. The new dosage has pulled me out of a 3 week depression and kept the angry/irritable mania at bay! Just wanted to brag and encourage everyone if they haven't found the right meds to keep trying and working with their doctor to find the right med. Keep up the hope!