When I miss one single dose of my Seroquel I start getting psychotic as soon as there is no Seroquel left in my system. I work nights and supposed to take meds at night,which I do not because I work on a busy med surg floor and I can not take it so doc told me to take it in the day before I go to bed but still it does not seem to have same effects as when I take it at night on my nights off. As soon as it is not in my system I start getting psychotic,paranoid,and manic. One thing for sure,Seroquel works.