Zoloft 50 mg. a day is a standard dose and I think you mean 0.5 mg. of Xanax . Both medications are often prescribed together and do not have any adverse interactions between the two. You might want to ask your pdoc to try clonazepam (Klonopin) instead of Xanax as the clonazepam is longer acting and seems to be smoother. Xanax is usually reserved for temporary, short-term use and can cause "rebound" anxiety in some users because of it's very short half-life. Both clonazepam and Xanax (alpralozam) are classified as "benzodiazepines" and can cause dependency issues after taking them for more than a few weeks. This means that should you be on Xanax (or another benzodiazepine) for longer than 3 weeks, you should never stop taking it abruptly and should have your dose tapered under the instructions of your pdoc.

I hope this helps. Laurie