I had not heard anyone put a number on it, but I consider 25% to be pretty good odds, just as good as any one SSRI I would think. In fact, I am surprised it is as high as 25%. I have tried Buspar for day to day anxiety but did not find that it helped. I had the sort of anxiety you get when you are going through a really stressful time in your life. So this was a rather extended period of situational anxiety, rather than an intrinsic disorder. The Buspar, however, did help me with social anxiety, which I have always had, although not cripplingly so, and this was not the reason I took the drug. So it was an unexpected benefit, but I only stayed on the med a few months since it didn't really help with anxiety. (It did have a totally cool side effect though--greatly enhanced sense of smell and taste--so for that reason I am glad I experienced it!) I tried Xanax and found I am very sensitive to it. It puts me to sleep or makes me kind of zoned out. So it wasn't much use during the day, but I found it very useful at night if I was lying awake unable to sleep due to anxiety. Worked great--put me right to sleep! I didn't take it long enough or regularly enough to become addicted. I also got a prescription for propranolol to serve the same function as I had wanted the Xanax for--to take on the spot, such as immediately before a predictable, stressful situation. It worked quite well and did not make me sleepy or zoned-out. It is a drug I don't hear mentioned much (for anxiety), but I found it a benign Xanax substitute.

Good luck with your quest. Sounds like you and your pdoc are really trying hard.