I'm also on Zoloft 100mg per day and I've been on it for about 5 years with a brief gap. I have Generalized Anxiety Disorder, Panic Disorder and dysthymia (depression). The Zoloft helps my depression, but is not so helpful anymore for my anxiety issues. I'm thinking of switching to a different medication. I am not familiar with Luvox. Is it an anti-depressant? Would you be taking it WITH the Zoloft or instead of the Zoloft? If I started taking luvox then they would stop the zoloft .Yeah luvox is anti depressant med I also have dysthmia and its tough dealing with .Zoloft make anxiety worse.Thanks 4 replying back cause it difficult dealing depression and anxiety .What your doctor got you on for the dysthmia cause right now they said since its mild they might not put me on nothing for it but I need something for it cause I have no engery and feeling tired all the time.I wish you luck with your meds cause meds get used to your body and it stops you from feeling better .Zoloft was a good med for anxiety but its seems that its not strong enough.When you first started zoloft did it made you more anxious and made you tired.

Wishing you all the best!