Thank you for your post! I've been on it now for about 2 weeks, first week was awesome as far as feeling good mentally and energy wise. Now though I am extremely tired but I don't think it is the depakote, I think it is the season change. I have had more appetite and I have gained about 5 lbs but I think it is just the stress I am under. I am considering switching though because I am getting an eye twitch, not sure if it is related but concerns me. Did you gain weight when you switched to Seroquel? that is my next option. Thanks again!