I have never had any reactions to the majority of meds I have taken however AD meds are new to me since I have only been on them for approx. 2 years and have only taken a few different types. This morning after taking the higher dose of effexor xr and the welbutrin I felt a little tired but after about and hour or so I noticed I could not keep my hands steady several hours later that has stopped. I have my kids this weekend and even though I love them and I am glad they are here I am still very much in my what seems to normal for me mode which is not too good. I have gotten pretty good at hiding my thoughts and feelings since I have learned nobody outside of a hospital or caregiver seems to really care. I know I should be doing something different when I am in my moods however exercise as far as walking even sitting for long periods is not something I can do anymore due to Chronic/ severe knee pain. My other problem with doing something I have no money so even if I wanted to go for a drive to a park somewhere I have to consider the amount of gas I use. I am not making excuses it is just my reality. It seems that most of you have been treated for quite sometime and have gotten over the hump so to speak me on the other hand I have a very long way to go, you cannot turn of in a manner of a couple of days or months which has taken many years to develope. I have tried so many things and it seems it is better to set myself up for failure then to reassure myself that this will work ( either way this turns out I will be prepared for it ). Sorry about being so negative if it was not for my kids and my mother I would not be here. I have no friends nothing I have caused my mother a lot of grief not as much as I have caused myself and I always am thinking if I was not here how much happier people would be and that would be if there was someone who actually cared. Maybe things will change and I know I need help but then again who am I?