I'm on Lamictal (150) and Wellbutrin (300). Cymbalta and Wellbutrin are both SNRI's..you have to wonder if just one or the other would do the trick...anyway, I was previously on Prozac (big mistake). Being on Lamictal alone brought on the deepest, blackest depressions I've ever had. Adding the Wellbutrin has helped a lot; I still get depressed but not even close to what it was. My doc won't up the Wellbutrin until I deal with some of the situations in my life that are contributing to it; a way to nudge me into therapy, which I have avoided. I will be starting CBT, but have also been doing a DBT skills workbook.