I totally agree that weight gain is a major part of non-compliance. I flat out refused to take any that put weight on me, and voila!! Here I am on different meds, coping well with a good diet and exercise. It's fundamental that weight loss=exercise+reduced calories, though. Even after my med change I had to get over the embarrassment and get my butt to the gym. You know what? Lots of people were just as big as I was. You can do it, too, BNL. Exercise is the key to breaking the cycle you mentioned above. After a med change, that is.