Hi sewerrats. Welcome! I totally agree with Jill that you should check with your psychiatrist. I also take 100 mg of Zoloft (sertraline). Like you, I have also tried to increase the dose but found it made my anxiety/agitation worse. I don't know if it would have worked itself out in the end if I'd persevered with the increase. I do feel I need to take a higher dose than this and my pdoc also wants me to try and increase. Sertraline also comes in splittable 25mg tablets. So it is possible to increase very gradually, say, by 12.5 mg at a time. Having said that, I even found that difficult. So I'm kind of stuck at 100 mg at the moment........

I hope you're able to get an appointment with your psychiatrist soon and that he/she can advise you on where to go from here with your dosage. Let us know how you get on !