Poseygurl - Unfortunately we all have to say that most people with treament resistant depression have to try a number of combinations of antidepressants and other drugs before finding the combination that works for them.

Have you ever considered ECT? It is by far the most efficacous treatment we have.

If the Zoloft combo is working for you - stick with it. Remember, an adequate trial for any antidepressant therapy is 8 - 10 weeks before giving up on it.

I hope this helps - Cam

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