Benedyl doesnt work for anxiety or depression. It is prescribed for allergies because it is an antihistamine. It is also prescribed for insomnia because it contains the drug Dyphenhydramine which is found in sleeping pills and is a depressant. It does not contain any antdepressant medications so it will not help with depression or anxiety. There are some meds that benedryl should NOT be taken with certain antidepressants.