I agree that it is usually trial and error, mostly error !! Most meds suit some people and not others. I have been on Quetiapine for about three years. It has been good in that it helps my sleep. I am sure it has quite a few side effects and I am now wondering if is the best thing for me. I have never tried Abilify. I will be asking my pdoc next time if there any alternatives to the Quetiapine.