i have a prob, my 100mg of sertraline my theraputic dose is failing . The tell tale sign,s of anxierty an mood swings, i have gone to 150mg in the last week, But i have to wait to see if i will improve, or if the med is pooping out an im adding more grief. Its a major blow to me as 100mg worked cool for a year an the side effects were bearable. I had the usual orgasm probs , but nothing major. Now i no 150 mg is going to nuke the sex side, an give more side effects,But i have no choise as i have tried to ride out the down feelings for weeks. i could change meds but to what, in my life i have been on most, an sertraline is about the best all round med.So have any of you guys gone up from 100 to 150 an had a cool result. If so how long before the extra 50mg kicked in. You would think adding the extra 50 mg would work straight away , but it dont work like that, at the moment im worse for taking the extra but i have to see it out. anyone out there done the same as im doing , an how long before results kicked in or not as the case may be.An are you glad you upped the dose./////////// FEED BACK WOULD BE COOL