I've been around and know many people involved in gangs, some no longer living. Your friend who is in trouble does have punishment coming but the severity of his punishment depends on what he has done like for example, how much money he owes, (if he owes any). Also what they'll do with him depends on the toughness of the gangs since you said "major" gangs I'm thinking gangs that are well known. I suggest you tell your friend to move him out of the state, but like a pervious poster posted stated he has to be 100% committed to changing, especially if he is in a gang whether it's one of the ones he has trouble with or another, this will make things much harder.

Sometimes gangs go after family members if they can't get the person they want, so if it's possible everyone should move or at least be on the lookout, but this again depends on what type of trouble he is in, or how much money he owes.

IMO, the police are not a good idea you didn't mention the names of the gangs but well known gangs have ties within the police department. Also, the police can't protect him 24/7. Those who involve the police are considered "snitches" they don't live very long. This again depends on which gangs you are speaking of.

I hope the best for your friend and her family. I know how tough it is to survive gang life.